Which of the following are characteristics of Hodgkin's disease? (Select all that apply.)
a. It is the most curable of all lymphomas.
b. It is distinguished by the presence of Philadelphia chromosome.
c. It is distinguished by the presence of Reed-Sternberg cells.
d. Skeletal pain is a common symptom.
e. Painless swelling of cervical, axillary, or inguinal nodes occurs.
f. Visual changes occur.
ANS: A, C, E
Hodgkin's disease is a lymphoma, which is a cancer of the lymph system. Its distinguishing feature is Reed-Sternberg cells, which make it different from all the other forms of lymphoma. Of all the lymphomas, Hodgkin's disease is the most curable type, even when the disease is widely spread at the time of diagnosis. Painless swelling in one or more of the common lymph node chains is a usual presentation. Swelling can range from barely perceptible to the size of a softball, occasionally even larger. Chronic myelogenous leukemia is characterized by the Philadelphia chromosome. Skeletal pain is a symptom of leukemias and multiple myeloma. Visual changes are associated with polycythermia vera.
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