The genes associated with color blindness and hemophilia are located on the X chromosome. If the recombination

frequency between these genes is 25%, what is the genetic map distance between them? Explain how you arrived at your
answer, and why calculating recombination frequencies are an important step in creating genetic maps. What will be an ideal response?


ANSWER: A genetic map is made in two steps: (1) Finding linkage between two genes establishes that
they are on the same chromosome, and (2) measuring how frequently crossing over takes
place between them establishes the distance between them. The units of distance are
expressed as a percentage of crossing over, where 1 map unit is equal to a 1% crossover
frequency (one map unit is also known as a centimorgan, or cM). Therefore, a 25%
recombination frequency is equal to 25 map units or cM.

Biology & Microbiology

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