A nurse is administering an antianxiety agent to a client. The nurse understands that long-term use of which of the following anxiolytics would be most likely to lead to physical or psychological tolerance? Select all that apply
A) Alprazolam
B) Buspirone
C) Hydroxyzine
D) Chlordiazepoxide
E) Doxepin
Ans: A, D
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Although long-term use of benzodiazepines such as alprazolam and chlordiazepoxide and nonbenzodiazepines such as buspirone, hydroxyzine, and doxepin can result in physical or psychological dependence, benzodiazepines are more likely to result in physical dependence and tolerance.
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