Familial hypercholesterolemia is a genetic disease that affects approximately one in 500 people worldwide. There is more than one genetic cause of the disease. Class I is often described as an autosomal dominant disease. Affected individuals have cholesterol levels >250 as children and often >300 as adults. However, homozygotes have cholesterol levels of >600 as children and can die of heart attacks in their 20s. These individuals entirely lack a functional LDL receptor.
Which of the following would be the best description of the inheritance of this form of hypercholesterolemia?
A) Dominant epistatic
B) Codominant
C) Incompletely dominant
D) Complementary
E) Recessive epistatic
C
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a. True b. False
What protects a cell and may help keep other cells at a distance?
a. cell wall
b. glycocalyx c. microfilaments d. middle lamella e. extracellular matrix
Which of these animals does not have a closed circulatory system?
A. earthworm B. fly C. leeches (a type of annelid) D. frogs E. killer whales
The perforin-granzyme pathway involves
A. the production of fever, which kills the pathogen. B. the production of antibodies toward the invading pathogen. C. the production of special cell-killing proteins that act on infected or abnormal cells. D. presenting the foreign antigen to B cells. E. binding CD95L to infected cells, which eventually leads to cell apoptosis.