The nurse knows that pregnancy affects the absorption, distribution, metabolism, and excretion of drugs. Which one is the least affected by pregnancy?
1. Distribution
2. Metabolism
3. Excretion
4. Absorption
Correct Answer: 2
Rationale 1: Distribution results in greater hemodilution of plasma proteins and drugs.
Rationale 2: Metabolism is the least affected by pregnancy.
Rationale 3: Excretion is enhanced by increases in renal plasma flow, glomerular filtration rate, creatinine clearance, and renal tubular reabsorption.
Rationale 4: Absorption is delayed related to changes in the gastrointestinal tract during pregnancy.
Global Rationale: Metabolism is the least affected by pregnancy. Distribution results in greater hemodilution of plasma proteins and drugs. Excretion is enhanced by increases in renal plasma flow, glomerular filtration rate, creatinine clearance, and renal tubular reabsorption. Absorption is delayed related to changes in the gastrointestinal tract during pregnancy.
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