The patient with Parkinson's disease who has received ongoing therapy with dopaminergic drugs suddenly develops akinesia after a period of overall improvement in clinical status
Assess the following interpretations and choose the one that is applicable to this patient.
a. The patient is now resistant to treatment with this type of drug.
b. The patient is showing the "on-off phenomenon."
c. The patient has developed an allergy to the drug.
d. The patient has received too little of the drug over time.
ANS: B
The "on-off phenomenon" is a sudden waning of patient response to a drug after an improvement in clinical status. It typically occurs in patients who have received long-term levodopa treatment, and it manifests as an abrupt onset of akinesia.
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