Three of the ten glycolysis enzyme reactions are not simply reversed in gluconeogenesis and require different enzymes because
A) these three glycolytic enzymes cannot catalyze the reaction in the reverse direction under any circumstances.
B) these three glycolytic steps are the most highly exergonic and thermodynamically difficult to reverse.
C) NAD+ needs to be generated from NADH at each of these three steps.
D) all three steps require hydrolysis of ATP for gluconeogenesis.
E) these three glycolytic enzymes are not present in the cells performing gluconeogenesis.
Answer: B
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