Identify which of the following describes how antigen processing and presentation of self antigens by thymic epithelial cells differs from that of antigen-presenting cells in peripheral tissues. (Select all that apply.)
a. Thymic epithelium expresses MHC class I molecules but not MHC class II molecules.
b. Thymic epithelium uses cathepsin L for proteolytic degradation of self proteins.
c. Thymic epithelium expresses MHC class II molecules but not MHC class I molecules.
d. Thymic epithelium uses the transcription factor AIRE to activate thymic expression of tissue-specific genes.
e. Thymic epithelium expresses transcription repressor protein FoxP3.
B,D
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