You have isolated the gene for a protein, nuculin (a protein that some people believe resides in the nuculus) that is normally localized to the nucleus. You locate in the gene the portion of the coding sequence that codes for the nuclear localization signal (NLS) and engineer it so that a positively charged amino acid in the signal is replaced by a nonpolar amino acid) You then insert the gene into some cells and observe where nuculin goes after its synthesis. What is the effect, if any?

a) Nuculin is not moved to the nucleus.
b) Nuculin is not made by the cell at all.
c) There is no effect.
d) Nuculin moves to the nucleus as it usually does.


Ans: a) Nuculin is not moved to the nucleus.

Biology & Microbiology

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