A dysfunctional cell lacks a signal peptidase and is unable to cleave the ER signal sequence from proteins translated in the ER. What will be the effect on the cell's proteins?
A. The cell will have no integral membrane proteins.
B. All cellular proteins will have an ER signal sequence.
C. There will be a common signal sequence at the C-terminus of all integral membrane proteins in the nuclear envelope.
D. All cellular proteins will become membrane proteins.
E. There will be a common signal sequence at the N-terminus of all integral membrane proteins in the plasma membrane.
Answer: E
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