Explain why myosin II in a sarcomere can produced force only for that sarcomere contraction and not for that sarcomere extension

What will be an ideal response?


Answer: In each half sarcomere, myosin heads on each end of a bipolar filament can step only toward the actin thin filament plus end, which is anchored to the Z line on that end of the sarcomere. This causes contraction of the sarcomere. To generate force for sarcomere extension, myosin II heads would need to produce force by stepping toward the minus end of the actin filament, which only myosin VI (of the myosins described in the text) is capable of.

Biology & Microbiology

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