A woman has been prescribed Climara, a transdermal estradiol patch. Which of the following should she be instructed by the nurse regarding the administration?

A) Avoid prolonged sun exposure at the patch site due to increased plasma concentrations.
B) The application of heat at the patch site will decrease effectiveness and result in pregnancy.
C) The medication, when exposed to sunlight, can increase the risk of breast cancer development.
D) Exposure of the medication to occasional cold will increase effectiveness with application once a month.


A
Feedback:
The total amount of drug absorbed and the resulting plasma drug concentrations from transdermal estrogen can increase during exposure to heat, so patients should be advised to avoid prolonged sun exposure in the area of the patch. The application of heat at the patch site will increase effectiveness. The medication's exposure to sunlight will not increase the risk of breast cancer. The medication's exposure to cold will not change its effectiveness.

Nursing

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