A client with Parkinson disease who is receiving entacapone (Comtan) is to be given epinephrine for cardiopulmonary resuscitation
The nurse should be aware that entacapone (Comtan) causes an increased effect of epinephrine on the heart due to which action?
1. Stimulation of the enzyme COMT in the synaptic cleft
2. Inhibition of the enzyme COMT in the synaptic cleft
3. Increased reuptake of the enzyme COMT from the synaptic cleft
4. Excessive secretion of the enzyme COMT from the synaptic vesicles
Correct Answer: 2
Rationale 1: Entacapone (Comtan) causes inhibition, not stimulation, of COMT in the synaptic cleft.
Rationale 2: Entacapone (Comtan) causes inhibition of COMT in the synaptic cleft. This causes an increased effect of epinephrine on the heart and blood pressure.
Rationale 3: Entacapone (Comtan) does not cause reuptake of COMT in the synaptic cleft.
Rationale 4: Entacapone (Comtan) does not cause excessive secretion of COMT.
Global Rationale: Entacapone (Comtan) causes inhibition of COMT in the synaptic cleft. This causes an increased effect of epinephrine on the heart and blood pressure. Entacapone (Comtan) does not cause reuptake of COMT in the synaptic cleft, nor does it cause excessive secretion of COMT.
You might also like to view...
A hospital responds to a local mass casualty event. Which action should the nurse supervisor take to prevent staff post-traumatic stress disorder during a mass casualty event?
a. Provide water and healthy snacks for energy throughout the event. b. Schedule 16-hour shifts to allow for greater rest between shifts. c. Encourage counseling upon deactivation of the emergency response plan. d. Assign staff to different roles and units within the medical facility.
An adolescent has frequent headaches accompanied by nausea and vomiting. What item is most appropriate for the nurse to include in the teaching plan for this adolescent patient?
A. How to give him- or herself an injection of medication B. The maximum daily dose of acetaminophen (Tylenol) C. Ways to manage temporary ptosis or rhinorrhea D. What to do in case of a seizure during the headache
In anticipation of the admission of a child with hereditary spherocytosis (HS) who is experiencing an aplastic crisis, what action should the nurse plan?
a. Secure an isolation room. b. Prepare for a transfusion of packed red blood cells. c. Anticipate preoperative preparation for a splenectomy. d. Gather equipment and medication for treatment of shock.
While assessing an unconscious client's neurological status, the nurse applies pain by pinching the sternocleidomastoid muscle. This technique is implemented because:
1. Pain will make abnormal motor responses observable. 2. An unconscious client's pain threshold is abnormally high. 3. Response to pain is an indicator of cognitive function. 4. The client is most likely to respond to pain at that site.