A nasopharyngeal aspirate is cultured on Bordet-Gengou agar, and growth is observed. The colonies are also subjected to a direct fluorescent antibody (DFA) stain, which is also positive. On the basis of these findings, the antimicrobial therapy that should be administered to the pa-tient is:

a. azithromycin.
b. gentamycin.
c. streptomycin.
d. imipenem.


A
Laboratories do not currently perform routine susceptibility testing of B. pertussis and B. para-pertussis because the organisms remain susceptible to erythromycin or the newer macrolides (e.g., clarithromycin, azithromycin), ketolides, quinolones, and additional antibiotics such as te-tracyclines, chloramphenicol, and trimethoprim-sulfamethoxazole combination. However, be-cause of three erythromycin-resistant isolates of B. pertussis, continued surveillance of B. per-tussis is advised.

Biology & Microbiology

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