What explains the increased incidence of bone marrow graft failure and cancer relapse when mature T cells are depleted from donor bone marrow before engraftment?
What will be an ideal response?
Mature T-cell depletion of bone marrow reduces GVHD, but graft failure and disease recurrence in cancer patients is an associated risk with this procedure. Apparently, alloreactive T-cell responses benefit engraftment by suppressing remnants of the recipient's immune system and removing residual cancer cells through a graft-versus-leukemia (GVL) effect.
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