Which of the following disorders would be consistent with the previously mentioned parameters?
a. Anemia of chronic disease
b. Aplastic anemia
c. Vitamin B12 deficiency
d. Thalassemia
ANS: C
Vitamin B12 deficiency leads to a macrocytic anemia with significant variation in size (therefore an increased RDW). Aplastic anemia is normocytic normochromic with a normal RDW; the anemia of chronic inflammation (disease) is either normocytic (MCV low normal) or slightly microcytic but normochromic and a normal or only a mildly elevated RDW. Thalassemia is a microcytic normochromic or hypochromic anemia with a normal RDW.
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