Epidermal growth factor (EGF) secreted from an anchor cell binds to its receptor on a nearby cell and initiates signal transduction. Which statement describing this signaling pathway is not correct?

A. In response to EGF binding to its receptor,
a series of protein phosphorylations occur
which amplify the signal at each step.
B. Certain key phosphorylated proteins enter
the nucleus and act as transcription activators
for the Notch gene.
C. The Notch protein is a transmembrane
protein that is inserted across the plasma
membrane and acts as a ligand for a Notch
receptor on the adjacent cell that will then
become a type 2 cell.
D. Transcription of the Notch ligand in the
type 1 cell results in an inhibition of the Notch
receptor in the type I cell and in an inhibition
of the EGF receptor in the adjacent cell
destined to differentiate into a type 2 cell.
E. EGF and Notch ligands are unique to
nematodes and only found in Caenorhabditis
elegans.


E

Biology & Microbiology

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