A group of nursing students are reviewing information about the actions of aspirin. The students demonstrate understanding of the information when they identify which action as being responsible for reducing fever?
A) Inhibition of prostaglandins
B) Dilation of peripheral blood vessels
C) Inhibition of platelet aggregation
D) Reduction in endorphins
Ans: B
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Salicylates lower body temperature by dilating peripheral blood vessels. The blood flows out to the extremities, resulting in the dissipation of the heat of fever, which in turn cools the body. Prostaglandin inhibition occurs with pain relief and is responsible for the drug's anti-inflammatory effects. Inhibition of platelet aggregation results in prolonged bleeding times and increases the risk of bleeding.
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