Which patient assessment will the nurse expect to observe when a patient has ingested alcohol while on disulfiram (Antabuse)?
a. Unconsciousness
b. Hypertension
c. GI bleeding
d. Severe vomiting
ANS: D
Severe vomiting occurs when alcohol is ingested while a patient is on disulfiram therapy. Disulfiram blocks the metabolism of acetaldehyde, a metabolite of alcohol. Elevated levels of acetaldehyde produce a reaction causing nausea, severe vomiting, sweating, throbbing headache, dizziness, blurred vision, and confusion. Disulfiram will not generally cause unconsciousness when alcohol is ingested with it, does not cause hypertension when taken in combination with alcohol, and does not cause GI bleeding.
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