What are the principal physiological stimuli that regulate acid secretion from the proton pump?
Standard Text: Select all that apply.
1. Gastrin
2. Histamine (H2)
3. Acetylcholine
4. Intrinsic factor
5. Dopamine
Correct Answer: 1,2,3
Rationale 1: Parietal cells receive messages from several sources, which tell them to increase or decrease acid production. These cells contain receptors for the hormone gastrin, which is a principal physiological stimulus that regulates acid secretion from the proton pump.
Rationale 2: Parietal cells receive messages from several sources, which tell them to increase or decrease acid production. These cells contain receptors for histamine (H2), which is a principal physiological stimulus that regulates acid secretion from the proton pump.
Rationale 3: Parietal cells receive messages from several sources, which tell them to increase or decrease acid production. These cells contain receptors for the neurotransmitter acetylcholine, which is a principal physiological stimulus that regulates acid secretion from the proton pump.
Rationale 4: Intrinsic factor does not play a role in the regulation of acid secretion from the proton pump.
Rationale 5: Dopamine does not play a role in the regulation of acid secretion from the proton pump.
Global Rationale: Gastrin, histamine (H2), and the neurotransmitter acetylcholine are the three principal physiological stimuli that regulate acid secretion from the proton pump. Intrinsic factor and dopamine do not.
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