When planning care for a trauma patient, the nurse understands that the response of the extrinsic coagulation pathway to tissue damage begins with the release of: A) factors VII and IX.
A) factors VII and IX.
B) platelet factor.
C) factor III.
D) factor VII.
C) factor III.
Explanation: A) The intrinsic pathway begins with the activation of proenzymes exposed to collagen fibers at the injury site. This pathway proceeds with the assistance of platelet factor, a platelet factor released by aggregating platelets. After a series of linked reactions, activated clotting factors combine to form an enzyme complex capable of activating factor X.
B) The intrinsic pathway begins with the activation of proenzymes exposed to collagen fibers at the injury site. This pathway proceeds with the assistance of platelet factor, a platelet factor released by aggregating platelets. After a series of linked reactions, activated clotting factors combine to form an enzyme complex capable of activating factor X.
C) The extrinsic pathway begins with the release of tissue factor (factor III) by damaged endothelial cells or peripheral tissues. The greater the damage, the more tissue factor is released, and the faster clotting occurs. Tissue factor then combines with Ca2+ and another clotting factor to form an enzyme complex capable of activating factor X, the first step in the common pathway.
D) The extrinsic pathway begins with the release of tissue factor (factor III) by damaged endothelial cells or peripheral tissues. The greater the damage, the more tissue factor is released, and the faster clotting occurs. Tissue factor then combines with Ca2+ and another clotting factor to form an enzyme complex capable of activating factor X, the first step in the common pathway.
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