An advantage of the use of monoclonal antibodies over polyclonal antibodies is that monoclonal antibodies:

Question

Standard Text: Select all that apply.
1. can be administered in the presence of fever.
2. have fewer side effects.
3. are administered by intramuscular administration.
4. are administered in a single dose.
5. can be administered in smaller doses.

Answer 1

Correct Answer: 2,5
Rationale 1: Monoclonal antibodies are contraindicated in clients with a fever of greater than 100°F.
Rationale 2: Monoclonal antibodies target a single type of cell, reducing side effects.
Rationale 3: Monoclonal antibodies must be administered intravenously.
Rationale 4: Multiple days of dosing are needed with monoclonal antibodies.
Rationale 5: Because of their specificity, smaller doses of monoclonal antibodies can be given.
Global Rationale: Because a single B cell produces a single antibody, it is called a monoclonal antibody (MAB). A MAB is very specific, targeting a single type of target cell or receptor. This allows greater effects on the target cell or receptor at lower doses and with fewer adverse effects than using polyclonal antibodies. They are contraindicated in the presence of a fever, are administered intravenously, and require multiple days of dosing.