Which of the following is the correct sequence of events leading to the polyuria and dehydration associated with diabetes mellitus?
A. Hyperglycemia ? glucose transport maximum exceeded ? glucose enters renal tubules ? glucose in urine raises osmolarity of tubular fluid ? osmotic diuresis
B. Osmotic diuresis ? glucose enters renal tubules ? glucose transport maximum exceeded ? glucose in urine raises osmolarity of tubular fluid ? hyperglycemia
C. Hyperglycemia ? glucose in urine raises osmolarity of tubular fluid ? glucose transport maximum exceeded ? glucose enters renal tubules ? osmotic diuresis
D. Hyperglycemia ? glucose enters renal tubules ? glucose transport maximum exceeded ? glucose in urine raises osmolarity of tubular fluid ? osmotic diuresis
E. Hyperglycemia ? glucose enters renal tubules ? glucose in urine raises osmolarity of tubular fluid ? osmotic diuresis ? glucose transport maximum exceeded
Answer: D
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