Normally, the central chemoreceptors responsible for triggering ventilation changes respond to which of the following?
a. Increased PaCO2 c. Decreased PaO2
b. Increased HCO3– d. Increased PaO2
A
Ventilation increases when the hydrogen ion concentration increases and decreases when the hydrogen ion concentration decreases. An increase in the partial pressure of carbon dioxide (PaCO2) causes the movement of carbon dioxide across the blood–brain barrier into the cerebrospinal fluid, stimulating the movement of hydrogen ions into the brain's extracellular fluid. Peripheral chemoreceptors respond to changes in PaO2 levels.
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