What is the drug of choice for the pharmacotherapy of Paget's disease?
1. Bisphosphonates
2. Selective estrogen-receptor modulators (SERMs)
3. Hormone therapy (HT)
4. NSAIDs
Correct Answer: 1
Rationale 1: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget's disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Rationale 2: Selective estrogen-receptor modulators (SERMs) is incorrect because this is not a treatment for Paget's disease.
Rationale 3: Hormone therapy (HT) is incorrect because this is not a treatment for Paget's disease.
Rationale 4: NSAIDs is incorrect because this is not a treatment for Paget's disease.
Global Rationale: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget's disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again. Selective estrogen-receptor modulators (SERMs) is incorrect because this is not a treatment for Paget's disease. Hormone therapy (HT) is incorrect because this is not a treatment for Paget's disease. NSAIDs is incorrect because this is not a treatment for Paget's disease.
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