What is the most serious clinical consequence of heparin-induced thrombocytopenia?
a. Hemorrhage
b. Thrombosis
c. Factor XII activation
d. Resistance to aspirin therapy
ANS: B
As many as 10% to 30% of patients with heparin-induced thrombocytopenia develop thrombotic problems. Patients who develop heparin-induced thrombocytopenia should be removed from heparin therapy as soon as the diagnosis is made, because continued heparin therapy can lead to significant morbidity and mortality. After discontinuation of heparin the platelet count begins to rise and should return to normal within a few days.
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