A client calls the office to ask a question regarding his animal's medication. He is currently giving his dog one antibiotic tablet twice a day to treat a skin infection. The client is planning on going on vacation and is wondering if his dog sitter could give four antibiotic tablets once every two days instead of one antibiotic tablet four times over two days. Because the total dose over the two
days would be the same, the client thinks that this would save the dog sitter some time and trouble. Is it recommended for this dog to receive its entire two-day dose at one time? Why or why not? Relate your answer to testing or test results performed by drug companies to get FDA approval.
What will be an ideal response?
Even though the total dose per two-day period is the same with both regimens, it is not recommended to give the entire dose at once. Since extensive testing is done on drugs to determine their effectiveness at a particular dose with minimal side effects, it is not advised to quadruple this dose for the client's convenience. This dog could develop toxic side effects unique to this drug if the dose given is greater than this drug's therapeutic index. This is especially true if this drug has a narrow therapeutic index.
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