Which conditions may occur with the administration of broad-spectrum antibiotics over an extended period of time?
a. Cross sensitivity
b. Immunosuppression
c. Secondary infection
d. Immunity
ANS: C
Secondary infections, such as oral thrush, genital and anal pruritus, and vaginitis, can occur with prolonged use of broad-spectrum antibiotics. Secondary infections result when normal flora are eliminated, which causes disease-producing microorganisms to multiply. Cross sensitivities develop during repeat exposures, not over a prolonged period. Immunosuppression does not develop over a prolonged interval of administration. Immunity is not produced by exposure to antibiotics.
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