The branched intermediates generated by recombination can be resolved in a number of ways. Which of the following is true of branched intermediates and their resolution?
A. Resolution of the branched intermediate can occur by dissociation of the invading strands and reannealing with their original complements. Gaps are filled in by DNA polymerase and the DNA is sealed by ligase. This is known as synthesis-dependent strand annealing (SDSA).
B. Resolution of the branched intermediate can proceed by double-strand break repair. Replication is completed by ligating the strands while they are still linked. Cleaving and rejoining the homologues can result in the original pair of chromosomes.
C. Resolution of the branched intermediate can proceed by double-strand break repair. Replication is completed by ligating the strands while they are still linked. Cleaving and rejoining the homologues can result in crossing over between the chromosomes.
D. Ligation of the branched intermediate formed by strand invasion results in two four-armed junctions called Holliday intermediates or junctions.
E. All of the choices given are correct.
E
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