What systems are activated by Hageman's factor? (Select all that apply.)
A) Kinin system
B) Histamine release system
C) Clotting cascade
D) Plasminogen system
E) Chemotaxis system
A, C, D
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Hageman's factor is responsible for activating at least three systems in the body: the kinin system; the clotting cascade, which initiates blood clotting; and the plasminogen system, which initiates the dissolution of blood clots. Histamine release is stimulated by cell damage. Arachidonic acid activates some leukotrienes that have a property called chemotaxis, which is the ability to attract neutrophils and to stimulate them and other macrophages to be very aggressive.
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