The nurse is providing chemoprophylaxis drug therapy for a client who will be traveling to a country with a high incidence of malaria. Which drugs are appropriate for chemoprophylaxis?
Standard Text: Select all that apply.
1. Chloroquine
2. Atovaquone-proguanil
3. Primaquine
4. Artemether-lumefantrine
5. Quinine sulfate
Correct Answer: 1,2,3
Rationale 1: Chloroquine is a medication that can be used for chemoprophylaxis of malaria.
Rationale 2: Atovaquone-proguanil is a medication that can be used for chemoprophylaxis of malaria.
Rationale 3: Primaquine is a medication that can be used for chemoprophylaxis of malaria.
Rationale 4: Artemether-lumefantrine is a medication used to treat an acute malarial attack and is not used for chemoprophylaxis.
Rationale 5: Quinine sulfate is a medication used to treat an acute malarial attack and is not used for chemoprophylaxis.
Global Rationale: Chloroquine (Aralen) is the traditional drug of choice, unless travel is to a region known to have a high incidence of chloroquine-resistant strains of Plasmodium. Several options are available for patients unable to take chloroquine or for those who are traveling to areas where chloroquine-resistant species are prevalent. These include the combination drugs atovaquone-proguanil (Malarone), doxycycline, mefloquine, or primaquine. Artemether-lumefantrine is a medication used to treat an acute malarial attack and is not used for chemoprophylaxis. Quinine sulfate is a medication used to treat an acute malarial attack and is not used for chemoprophylaxis.
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