The client is an elderly woman with mild liver damage due to hepatitis. The nurse is aware that the client may need reduced dosages of medications because:
a. her kidneys cannot eliminate medications at the usual rate.
b. the drugs may accumulate in the client's body and produce toxicity.
c. the rate of absorption will increase, allowing more drug to enter the bloodstream.
d. liver damage will cause drugs to bind to plasma proteins.
ANS: B
Feedback
A Incorrect: Liver damage does not affect the kidneys's ability to excrete the drug.
B Correct: This is a cumulative effect of both the drug and active metabolites.
C Incorrect: Hepatic insufficiency will not increase drug absorption.
D Incorrect: Drugs binding to plasma proteins is a part of drug distribution not biotransformation.
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