The patient is receiving valproic acid (Depakene) for treatment of seizures. The patient has also been taking a daily 81 mg aspirin tablet prophylactically for a cardiac condition. What would the nurse be most likely to observe?
1. An increase in seizure activity
2. Stevens-Johnson syndrome
3. Migraine headaches and generalized irritability
4. Bleeding from the gums and bruising of the skin
Correct Answer: 4
Rationale: Valproic acid (Depakene) can prolong bleeding time; concomitant aspirin use can cause severe bleeding. Increased seizure activity is not associated with valproic acid (Depakene) and aspirin use. Stevens-Johnson syndrome is a side effect of valproic acid (Depakene); its occurrence is not increased with concomitant aspirin use. Migraine headaches and generalized irritability do not result from valproic acid (Depakene) and aspirin use.
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