What conclusions were drawn from the Acute Respiratory Distress Syndrome Network (ARDSnet) study regarding ventilator-induced lung injury?
A. The tidal volume used to ventilate a patient is not as important as the pressure delivered to the lungs.
B. Low tidal volume ventilation attenuates ventilator-induced lung injury (VILI).
C. Plateau pressure levels are the most important consideration in preventing VILI.
D. PEEP levels used in conjunction with mechanical ventilation are the most important consideration in minimizing VILI?
?ANS: B
A. Incorrect response: See explanation B.
B. Correct response: When the ARDSnet study was terminated, mortality was reduced from 40% to 31% with low tidal volume intervention. Patients receiving lower tidal volumes had significantly more ventilator-free days. The ARDSnet trial clearly established the benefits of using low tidal volumes to ventilate patients with ALI and presented compelling evidence in humans for VILI.
C. Incorrect response: See explanation B.
D. Incorrect response: See explanation B.
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