Describe the monoamine hypothesis of depression, and discuss evidence that supports this hypothesis.
What will be an ideal response?
Depression (without mania) reflects profound changes in mood, appetite, movement, and sleep. The monoamine hypothesis argues that depression reflects a reduced level of activity of the monoamine transmitters, specifically norepinephrine and serotonin (5-HT). A variety of treatments exist for depression (monoamine oxidase inhibiters, tricyclics, serotonin reuptake inhibitors, electroconvulsive therapy, and sleep deprivation). The tricyclic drugs block the reuptake of norepinephrine and 5-HT, while the serotonin reuptake inhibitors block only serotonin reuptake (resulting in more serotonin). The tryptophan depletion procedure lowers brain serotonin levels and can reinstate depression.
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