The nurse is researching the pathophysiology and etiology of major depressive disorder. What will the nurse learn is true regarding neurological structure alterations and the development of major depressive disorder? Select all that apply

Question

1. An increase in the central nervous system (CNS) volume is associated with major depressive disorder.
2. Excessive levels of serotonin and norepinephrine have been associated with major depressive disorder.
3. Impairments to cerebral structural plasticity and neuronal cellular resilience have been noted with major depressive disorder.
4. An increase in the numbers and sizes of glia and neurons in some areas of the brain have been noted with major depressive disorder.
5. Dysfunction of cerebral blood flow and glucose metabolism in some areas of the brain has been noted with major depressive disorder.

Answer 1

Answer: 3, 5
Explanation: Neurological structure alterations associated with the development of major depressive disorder include impairments to cerebral structure plasticity and neuronal cellular resilience, as well as dysfunctions of cerebral blood flow and glucose metabolism in the prefrontal cortical, striatal, and limbic systems. Excessive levels of serotonin and norepinephrine have been associated with anxiety disorder, not major depressive disorder. A decrease, not increase, in both CNS volume and the numbers and sizes of glia and neurons has been associated with major depressive disorder.