The surrogate light chain operating during pre-B-cell development is made up of VpreB:?. Its expression with ? on the pre-B-cell surface is an important checkpoint in B-cell maturation
Name the T-cell analog of VpreB:?5 and discuss how it is functionally similar.
What will be an ideal response?
The analog of VpreB:?5 in developing T cells is the protein preT?(pT?), which combines with the T-cell receptor ? chain, the first of the two T-cell receptor chains to be expressed, to form the pre-T-cell receptor. The ? chain, like the immunoglobulin heavy chain, contains V, D, and J segments. pT? also binds CD3 and ? components to this complex, and the assembly of the complete complex induces T-cell proliferation and the cessation of rearrangement at the TCR? loci (leading to allelic exclusion). Formation of the analogous pre-B-cell receptor complex of VpreB:?5 and heavy chain with Ig? and Ig? in B cells similarly prevents further rearrangement of the heavy-chain loci.
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Cryotherapy:
A) requires that the whole body be treated at the same time. B) causes the blood vessels to contract and slows down the flow of blood to the area. C) increases the flow of blood to the area and contracts the blood vessels. D) is a type of hydrotherapy.
What muscle helps to support the medial longitudinal arch?
A. Flexor Hallucis Longus B. Flexor Digitorum Longus C. Posterior tibial is D. Fibularis Brevis
Identify the next step Australian researchers want to identify about the affects of increased muscular strength on the brain.
A. increases in cognitive function B. increases in brain size C. decreases in Alzheimer's disease symptoms D. decreases in memory
?Investigations on the effect of school-required community service on academic performance found _______________ (positive/negative) links between the two.
Fill in the blank(s) with the appropriate word(s).