The chemical properties of messengers affect how they are able to communicate with the target cell. Hydrophobic and hydrophilic messengers have many differences in the way they function
Discuss these differences and how they relate to the hydrophobicity/philicity.
What will be an ideal response?
Answer: Hydrophobic messengers dissolve easily in lipids. Therefore, the membranes are not barriers to them. As a result, they are able to diffuse into a cell and use intracellular receptors, and must be made on demand because they cannot be stored in vesicles. They may also use transmembrane receptors, resulting in more rapid effects. In addition, they must be transported by protein carriers over longer distances because they cannot be dissolved in the blood at high concentrations. Hydrophilic messengers, on the other hand, dissolve easily in the blood and cytosol, but cannot pass through cell membranes. Therefore, they must use transmembrane receptors and can be made ahead and stored in vesicles. They are then exocytosed when it is time for release. Because they bind to transmembrane receptors, their effects are rapid, but many are short-lived.
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In adipose tissue, hormone-sensitive lipase
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