Kinases are enzymes that can phosphorylate (transfer phosphate groups onto) macromolecules such as proteins. A particular kinase, Kinase 1 is known to promote cell division. It promotes cell division by phosphorylating Protein X. Phosphorylation of Protein X activates Protein X. Once activated, Protein X stimulates the production of other proteins such as Protein Y and Z that directly promote cell division. In order to function, Kinase 1 requires the presence of Metal A. However, in the presence of Protein A, Kinase 1 is nonfunctional. From the description, what is considered a cofactor of Kinase 1?
A. Protein X
B. Protein Y
C. Protein Z
D. Metal A
E. Protein A
D. Metal A
Metal A is required for Kinase 1 to function, and thus is a cofactor for this kinase.
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