Which of the topical antimicrobial agents is commonly used as a broad-spectrum and fights against gram-positive and -negative bacteria?

Question

a. Pure silver c. Mafenide acetate cream
b. Bacitracin d. Silver sulfadiazine

Answer 1

D
SSD (Silvadene cream) is a broad-spectrum antimicrobial agent with bactericidal action against many gram-negative and -positive bacteria associated with burn wound infection. Mafenide acetate cream penetrates through burn eschar and is bacteriostatic against many gram-negative and -positive organisms. Its use is limited because the application is uncomfortable for the patient because it creates a burning sensation, and it is rapidly absorbed, requiring dressing changes two or three times daily. It is used routinely for coverage of small wounds. Bacitracin ointment is a topical agent applied to superficial burns and facial burns. Bacitracin is effective against gram-positive organisms but not against gram-negative organisms or fungal organisms. Silver has long been used for the treatment of wounds because of its broad-spectrum bacteriostatic properties. The wound moisture activates the silver and releases it into the wound. An advantage of silver dressings is that the dressing does not need to be changed daily because of the sustained release of silver. Silver dressings should be used judiciously and limited to 4 to 6 weeks despite the current absence of negative systemic or local consequences.