A patient who has been prescribed primidone (Mysoline) also takes warfarin (Coumadin). Which laboratory blood test results indicate to the nurse a possible drug interaction?
a. Hematocrit 32%
b. Hemoglobin 11.2 g/dL
c. Blood urea nitrogen (BUN) 21 mg/dL
d. International normalized ratio (INR) 0.5
D
Primidone decreases the effectiveness of anticoagulants, including warfarin. Warfarin effective-ness is measured by the INR. This value should be no less than 1.5 in a patient taking warfarin. With an INR level of only 0.5 the patient is at risk for forming clots and having a stroke, heart attack, pulmonary embolism, or deep vein thrombosis.
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