How would you expect a disease of cartilage formation to affect bone development?
A. Cartilage is used for other tissues, not bone, so it will not affect bone development.
B. The epiphysis is formed of cartilage so that will be disrupted, but otherwise the bone will be normal.
C. It would greatly disrupt bone development, since bones are originally formed of cartilage that becomes replaced.
D. Cartilage defects will affect bone only via the effect on tendons and ligaments.
Answer: C
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