A patient with Parkinsonism has been told that the levodopa prescribed is no longer controlling the disease. What drug would the nurse question if ordered as adjunctive therapy?
A) Diphenhydramine (Benadryl)
B) Pramipexole (Mirapex)
C) Trihexyphenidyl (Artane)
D) Vitamin B6
D
Feedback:
Vitamin B6 would further decrease the therapeutic effects of levodopa and is contraindicated with levodopa, so the nurse would question this order. Pramipexole, diphenhydramine, and trihexyphenidyl are all useful adjunctive drugs when Parkinson's disease is no longer controlled with levodopa therapy alone.
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