In the following clinical question, what is the Comparison (C component): Does chronic stress affect inflammatory responses in older men with atherosclerotic disease?
A) Chronic stress
B) Inflammatory response
C) Atherosclerotic disease
D) There is no "C" component
D
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In the PICO acronym, P stands for the population or patients (older men with atherosclerotic disease); I stands for the intervention, influence, or exposure (chronic stress); C stands for the component that is needed (there is no intervention or influence of interest contrasted with a specific alternative); and O stands for the outcomes (inflammatory response).
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