A client is taking a medication for a condition whose indication is not listed and asks the nurse why the health care provider would prescribe this drug. Which response by the nurse is the most appropriate?
1. "Some medications may be used for conditions for which they have not been approved. This is called an ‘off-label' indication."
2. "Some medications may be used as a prototype drug for a specific condition and are not listed in the nursing drug handbook."
3. "A medication can only be used for the specific condition for which it was approved."
4. "This is a generic drug, and not all generic drugs are in the nursing drug handbook. Only trade name drugs are listed."
Correct Answer: 1
Rationale 1: When a drug is prescribed for a condition for which it has not been approved, this is called an "off-label" indication.
Rationale 2: Prototype drugs are the early drugs to which all other drugs in the same class are compared. These drugs are FDA approved and can be found in the nursing drug handbook.
Rationale 3: Some drugs are used for conditions for which they have not been approved.
Rationale 4: All drugs, generic or trade name, are listed in the nursing drug handbook.
Global Rationale: When a drug is prescribed for a condition for which it has not been approved, this is called an "off-label" indication. This is the most appropriate response by the nurse. Prototype drugs are the early drugs to which all other drugs in the same class are compared. These drugs are FDA approved and can be found in the nursing drug handbook. Some drugs are used for conditions for which they have not been approved. All drugs, generic or trade name, are listed in the nursing drug handbook.
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