Transmission genetics ____
a. studies the pattern of inheritance as traits are passed from generation to generation
b. reconstructs the pattern of inheritance associated with a trait as it passes through several generations
c. maps genes to study chromosome structure and abnormalities in chromosome numbers and organization
d. uses recombinant DNA technology to identify, isolate, and produce millions of copies of genes that can be studied in the laboratory
e. sequences the complete human genome
a
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You are leading a team of researchers at a pharmaceutical company. Your goal is to design drugs that help fight cancer. Specifically, you want to focus on drugs that bind to and inactivate certain proteins, thereby halting cell cycle progression. One of your team members suggests targeting the retinoblastoma (Rb) protein and inhibiting this protein. Will this approach be successful? Why or why not?
A. This approach will not be successful. Rb is tumor-suppressor protein, and functions to inhibit the action of a number of cell cycle regulatory proteins. A drug designed to inactivate the Rb protein would essentially create the same situation as in as a cell that lacks both copies of the Rb gene. Lack of Rb activity would release the inhibition of cell cycle regulatory proteins, thereby promoting cell cycle progression, rather than halting it. B. This approach will be successful. Rb is an oncogene, and functions to activate a number of cell cycle regulatory proteins. A drug designed to inactivate the Rb protein would halt the cell cycle in cells that contain an active Rb. As a result, cancer cells expressing a constitutively active Rb protein would be good targets for this type of therapeutic. C. This approach will be successful. Rb is tumor-suppressor protein, and functions to inhibit the action of a number of cell cycle regulatory proteins. A drug designed to inactivate the Rb protein would activate cell cycle inhibition. Lack of Rb activity would therefore inhibit the cell cycle regulatory proteins. D. This approach will not be successful. Rb is an oncogene, and functions to activate a number of cell cycle regulatory proteins. A drug designed to inactivate the Rb protein would actually activate cell cycle progression. As a result, this drug would likely make this situation worse for patients whose cancer cells contain mutant Rb. Clarify Question · What is the key concept addressed by the question? · What type of thinking is required? · What key words does the question contain and what do they mean? Gather Content · What do you know about Rb? How does it relate to the question? Consider Possibilities · What other information is related to the question? Which information is most useful? Choose Answer · Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer? Reflect on Process · Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
The holozyme is formed when the core enzyme associates with
A. Start codons B. b C. b' D. ? E. a
Which statement is true?
A) A line of lobe-finned fishes gave rise to tetrapods, and a line of tetrapods gave rise to modern amphibians. B) A line of tetrapods gave rise to chordates, and a line of lobe-finned fishes gave rise to tetrapods. C) A line of amphibians gave rise to tetrapods, and a line of lobe-finned fishes gave rise to modern amphibians. D) Tetrapods and amphibians evolved at approximately the same time, while lobe-finned fishes evolved 2 million years later.
All adenoviruses cause mild respiratory disease
Indicate whether the statement is true or false