A patient is given Abelcet instead of amphotericin B. What is the advantage of Abelcet over amphotericin B?
A) It is a newer medication with a lower cost.
B) It is the same as amphotericin B in hepatotoxicity.
C) It reaches higher concentration in diseased tissue.
D) It constricts afferent renal arterioles to reduce blood flow.
C
Feedback:
Lipid formulations, such as Abelcet, reach higher concentrations in diseased tissues than in normal tissues, so larger doses can be given to increase therapeutic effects. Abelcet does not cost less than amphotericin B. Abelcet has fewer side effects than amphotericin B. Amphotericin B constricts afferent renal arterioles to reduce blood flow.
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