Slowed gastrointestinal motility and delayed gastric emptying time, coupled with a decrease in gastrointestinal blood flow in older adults, affect the
a. Absorption of medications
b. Distribution of ingested drugs through the body
c. General intolerance of oral medications experienced by older adults
d. Excretion of most drugs through the bowel
A
The aging changes in the gastrointestinal system greatly affect the absorption of drugs that are taken orally. Aging changes seem to decrease cumulatively the absorption of most medications. Response B is incorrect because even though distribution is decreased in the older adult, it is because of vascular, hydration, or decreased muscle mass and increased fat stores, not because of changes in the gastrointestinal tract. Response C is incorrect because it is an overgeneralization to say that older people have a "general intolerance of oral medications." Response D is also false because most medications are excreted by the kidneys, not the bowel.
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