The client receives disulfiram (Antabuse) and asks the nurse what will happen if alcohol is consumed while taking this drug. What is the best response by the nurse?

1. "It really depends on how much alcohol you drink."
2. "Headache and nausea or vomiting are the most common effects."
3. "There is a good chance you will become very euphoric."
4. "Most people experience severe depression and suicidal thoughts."


2

Rationale 1:"It really depends on how much alcohol you drink" is incorrect because euphoria, severe depression, and suicidal thoughts do not occur. These are not symptoms of an accumulation of acetaldehyde in the blood. Any amount of alcohol will result in symptoms because disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase.
Rationale 2:"Headache and nausea or vomiting are the most common effects." Disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase, the enzyme that metabolizes alcohol. If alcohol is consumed while taking disulfiram (Antabuse), the client becomes violently ill within 5–10 minutes, with headache, shortness of breath, nausea or vomiting, and other unpleasant symptoms. These symptoms are the result of an accumulation of acetaldehyde in the blood.
Rationale 3:"There is a good chance you will become very euphoric" is incorrect because euphoria, severe depression, and suicidal thoughts do not occur. These are not symptoms of an accumulation of acetaldehyde in the blood. Any amount of alcohol will result in symptoms because disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase.
Rationale 4:"Most people experience severe depression and suicidal thoughts" is incorrect because euphoria, severe depression, and suicidal thoughts do not occur. These are not symptoms of an accumulation of acetaldehyde in the blood. Any amount of alcohol will result in symptoms because disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase.

Global Rationale: "Headache and nausea or vomiting are the most common effects." Disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase, the enzyme that metabolizes alcohol. If alcohol is consumed while taking disulfiram (Antabuse), the client becomes violently ill within 5–10 minutes, with headache, shortness of breath, nausea or vomiting, and other unpleasant symptoms. These symptoms are the result of an accumulation of acetaldehyde in the blood. "It really depends on how much alcohol you drink" is incorrect because euphoria, severe depression, and suicidal thoughts do not occur. These are not symptoms of an accumulation of acetaldehyde in the blood. Any amount of alcohol will result in symptoms because disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase. "There is a good chance you will become very euphoric" is incorrect because euphoria, severe depression, and suicidal thoughts do not occur. These are not symptoms of an accumulation of acetaldehyde in the blood. Any amount of alcohol will result in symptoms because disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase. "Most people experience severe depression and suicidal thoughts" is incorrect because euphoria, severe depression, and suicidal thoughts do not occur. These are not symptoms of an accumulation of acetaldehyde in the blood. Any amount of alcohol will result in symptoms because disulfiram (Antabuse) inhibits acetaldehyde dehydrogenase.

Nursing

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