A 22-year-old female whose brother is diagnosed with Duchenne muscular dystrophy (DMD) wants to know if her children will inherit it. A fairly accurate test to identify female carriers of the disease is measurement of serum levels of:
a. dystrophin.
b. myoglobin.
c. creatine kinase (CK).
d. troponin 1.
ANS: C
Diagnosis is confirmed by measuring the blood CK level, which is sometimes 100 times the nor-mal level, with confirmation by genetic testing for mutations in the dystrophin gene.
None of the other options is relevant to this screening.
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